Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drug resistance and the P-glycoprotein homologues of Plasmodium falciparum.

Seminars in cell biology - 1 Feb 1993

Cowman A F, Karcz S

Abstract excerpt

The chloroquine resistance phenotype of Plasmodium falciparum shares many similarities to multi-drug resistance in tumour cells and this has led to the identification of two mdr-like genes (pfmdr1, pfmdr2) from this human pathogen. The pfmdr1 gene has been linked to the chloroquine resistance phenotype, although a genetic cross appears to contradict these results. Analysis of drug resistant mutants selected in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Carrier Proteins
Share to Chloroquine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance

Share to Gene Expression

Share to Membrane Glycoproteins

Share to Phenotype

Share to Protozoan Proteins

Source

Identifiers

PMID: 8095826
DOI: 10.1006/scel.1993.1004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drug resistance and the P-glycoprotein homologues of Plasmodium falciparum.PMID 8095826Read ↗

Genetic and biochemical aspects of drug resistance in malaria parasites.Semantic proximity Read ↗

Chloroquine resistance of Plasmodium falciparum: further evidence for a lack of association with mutations of the pfmdr1 gene.Semantic proximity Read ↗

Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum.Semantic proximity Read ↗

Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum.Semantic proximity Read ↗

Multiple drug resistance genes in malaria -- from epistasis to epidemiology.Semantic proximity Read ↗

pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: a functional and evolutionary perspective.Semantic proximity Read ↗

Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number.Semantic proximity Read ↗

Genetic analysis of mefloquine-resistant mechanism of Plasmodium falciparum.Semantic proximity Read ↗

Sequence and gene expression of chloroquine resistance transporter (pfcrt) in the association of in vitro drugs resistance of Plasmodium falciparum.Semantic proximity Read ↗

Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates.Semantic proximity Read ↗

Amplification of pfmdr1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from ThailandSemantic proximity Read ↗

In vitro sensitivities of Plasmodium falciparum isolates from the China-Myanmar border to piperaquine and association with polymorphisms in candidate genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.