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Article

Drug resistance and the P-glycoprotein homologues of Plasmodium falciparum.

Seminars in cell biology - 1 Feb 1993

Cowman A F, Karcz S

Abstract excerpt

The chloroquine resistance phenotype of Plasmodium falciparum shares many similarities to multi-drug resistance in tumour cells and this has led to the identification of two mdr-like genes (pfmdr1, pfmdr2) from this human pathogen. The pfmdr1 gene has been linked to the chloroquine resistance phenotype, although a genetic cross appears to contradict these results. Analysis of drug resistant mutants selected in...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Carrier Proteins
Chloroquine
Drug Resistance
Gene Expression
Mefloquine
Membrane Glycoproteins
Phenotype
Protozoan Proteins

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Identifiers

PMID: 8095826
DOI: 10.1006/scel.1993.1004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8095826-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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