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Article

Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum.

Nature - 24 Feb 2000

Reed M B, Saliba K J, Caruana S R, Kirk K, Cowman A F

Abstract excerpt

Throughout the latter half of this century, the development and spread of resistance to most front-line antimalarial compounds used in the prevention and treatment of the most severe form of human malaria has given cause for grave clinical concern. Polymorphisms in pfmdr1, the gene encoding the P-glycoprotein homologue 1 (Pgh1) protein of Plasmodium falciparum, have been linked to chloroquine resistance; Pgh1 has...

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Identifiers

PMID: 10706290
DOI: 10.1038/35002615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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