Article
Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates.
Memorias do Instituto Oswaldo Cruz - 1 Nov 2009
Gama Bianca Ervatti, Oliveira Natália Ketrin Almeida de, Souza José Maria de, Daniel-Ribeiro Cláudio Tadeu, Ferreira-da-Cruz Maria de Fátima
Abstract excerpt
Plasmodium vivax control is now being hampered by drug resistance. Orthologous Plasmodium falciparum genes linked to chloroquine or sulfadoxine-pyrimethamine chemoresistance have been identified in P. vivax parasites, but few studies have been performed. The goal of the present work is to characterise pvmdr1 and pvdhfr genes in parasite isolates from a Brazilian endemic area where no molecular investigation had...
Topics
- Animals
- Brazil
- Genes, Protozoan
- Humans
- Insecticide Resistance
- Malaria, Vivax
- Multidrug Resistance-Associated Proteins
- Mutation
- Plasmodium vivax
- Polymorphism, Single Nucleotide
- Protozoan Proteins