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Article

Molecular alterations of cells resistant to platinum drugs: role of PKCalpha.

Biochimica et biophysica acta - 1 Jan 2006

Righetti Sabina C, Perego Paola, Carenini Nives, Corna Elisabetta, Dal Bo Laura, Cedrola Sabrina, La Porta Caterina A M, Zunino Franco

Abstract excerpt

Development of resistance to platinum compounds may involve not only overexpression of defence mechanisms but also alterations in cellular response to the drug-induced genotoxic stress. To investigate the cellular bases of response to platinum compounds, we examined the profile of gene expression of ovarian carcinoma cells exhibiting sensitivity (A2780) or resistance (A2780/BBR3464) to platinum compounds. Using...

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Source

Identifiers

PMID: 16473140
DOI: 10.1016/j.bbamcr.2005.12.007

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MARCKS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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