Article
Highly frequent homozygous deletion of the p16 gene in esophageal cancer cell lines.
Biochemical and biophysical research communications - 15 Sept 1994
Igaki H, Sasaki H, Kishi T, Sakamoto H, Tachimori Y, Kato H, Watanabe H, Sugimura T, Terada M
Abstract excerpt
To study the involvement of the p16 tumor suppressor gene in esophageal cancer development, we examined homozygous deletion of the p16 gene in 13 human esophageal cancer cell lines and 9 gastric cancer cell lines, in which some of genetic alterations have already been characterized. By Southern blot analysis, homozygous deletion was observed in 12 out of the 13 esophageal cancer cell lines (92%), in 2 out of a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.