Article
In vitro selection of resistance in Escherichia coli and Klebsiella spp. at in vivo fluoroquinolone concentrations.
BMC microbiology - 21 Apr 2010
Drago Lorenzo, Nicola Lucia, Mattina Roberto, De Vecchi Elena
Abstract excerpt
BACKGROUND: Fluoroquinolones are potent antimicrobial agents used for the treatment of a wide variety of community- and nosocomial- infections. However, resistance to fluoroquinolones in Enterobacteriaceae is increasingly reported. Studies assessing the ability of fluoroquinolones to select for resistance have often used antimicrobial concentrations quite different from those actually acquired at the site of...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Ciprofloxacin
- DNA Gyrase
- DNA Mutational Analysis
- DNA Topoisomerase IV
- Dioxolanes
- Drug Resistance, Bacterial
- Escherichia coli
- Escherichia coli Infections
- Fluoroquinolones