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Article

Fluoroquinolone-resistant Brucella melitensis mutants obtained in vitro.

International journal of antimicrobial agents - 1 Sept 2009

Lázaro Francisco García, Rodríguez-Tarazona R Elisa, García-Rodríguez José Angel, Muñoz-Bellido Juan Luis

Abstract excerpt

Three fluoroquinolone-resistant Brucella melitensis mutants were obtained after successive passages on norfloxacin-containing agar plates. The original strain was B. melitensis biovar 2 ATCC 23457. Mutants emerged at frequencies ranging between 1 x 10(-6) and 3 x 10(-8). The three mutants showed a gyrA Ala71-->Ser mutation as well as insertion of Ala340. No mutations were observed in the parC and gyrB genes....

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PMID: 19243922
DOI: 10.1016/j.ijantimicag.2008.12.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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