Article
Phenotypic characterization of quinolone-resistant mutants of Enterobacteriaceae selected from wild type, gyrA type and multiply-resistant (marA) type strains.
The Journal of antimicrobial chemotherapy - 1 Aug 1991
Piddock L J, Hall M C, Walters R N
Abstract excerpt
The NCTC type strains of Escherichia coli, Enterobacter cloacae, Serratia marcescens and Klebsiella pneumoniae were exposed to 3, 5 and 10 x MIC of nalidixic acid, enoxacin, ciprofloxacin, PD 117596 and PD 127391. From each strain a mutant with a high MIC of quinolones alone (gyrA) and a mutant with intermediate resistance to quinolones, some beta-lactams, chloramphenicol and tetracycline (multiply resistant,...
Topics
- Anti-Infective Agents
- Ciprofloxacin
- Drug Resistance, Microbial
- Enoxacin
- Enterobacter cloacae
- Enterobacteriaceae
- Escherichia coli
- Fluoroquinolones
- Klebsiella pneumoniae
- Mutation