Article
Effect of mutations in rev gene of SIVmac on virus replication.
AIDS research and human retroviruses - 1 Jan 1994
Aavik E, Hakkarainen K, Krohn K J
Abstract excerpt
The functional activity of SIVmac251 Rev was altered by introducing amino acid changes inside and chain termination mutations after the Rev response element-binding region (RBR) of the protein. The effects of specific mutations were evaluated by transfecting proviral DNAs into the HeLa cell line and into HeLa cells constitutively expressing either HIV-1 Rev or HTLV-1 Rex proteins. Cell-free supernatants from...
Topics
- Amino Acid Sequence
- Cell Line
- Gene Products, rev
- Genes, rev
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- SAIDS Vaccines
- Simian Immunodeficiency Virus
- Transfection
- Vaccines, Attenuated