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Article

A trans-dominant negative HIV type 1 Rev with intact domains of NLS/NOS and NES.

AIDS research and human retroviruses - 1 Jul 2002

Fang Jianhua, Kubota Satoshi, Pomerantz Roger J

Abstract excerpt

The nuclear diffusion inhibitory signal (NIS) is a 15-amino acid peptide motif (10-24; EDLLKAVRLIKFLYQ) in the N-terminus of the HIV-1 Rev protein. NIS appears to be involved in maintaining the proper nucleocytoplasmic trafficking and intracellular stability of HIV-1 Rev. Deletion in NIS leads to Rev functional inactivity, and these data led to further investigation of its possible inhibitory effects on Rev...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Gene Products, rev

Share to HIV Core Protein p24

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Share to rev Gene Products, Human Immunodeficiency Virus

Source

Identifiers

PMID: 12167277
DOI: 10.1089/088922202760072320

Genes

NES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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