Article
A-Raf associates with and regulates platelet-derived growth factor receptor signalling.
Cellular signalling - 1 Jul 2005
Mahon Elizabeth S, Hawrysh Andrea D, Chagpar Ryaz B, Johnson Lindsey M, Anderson Deborah H
Abstract excerpt
Raf kinases are important intermediates in epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) mediated activation of the mitogen-activated protein kinase (MAPK) pathway. In this report, we show that the A-Raf kinase is associated with activated EGF receptor complexes and with PDGF receptor (PDGFR) complexes independent of prior PDGF treatment. The ability of A-Raf to associate with receptor...
Topics
- Animals
- COS Cells
- Chlorocebus aethiops
- ErbB Receptors
- Humans
- Mice
- Mutation
- NIH 3T3 Cells
- Organ Specificity
- Phosphatidylinositol 3-Kinases
- Phospholipase C gamma
- Phosphorylation
- Proto-Oncogene Proteins A-raf
- Proto-Oncogene Proteins c-raf
- Receptors, Platelet-Derived Growth Factor
- Signal Transduction
- Type C Phospholipases