Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation.

The Journal of biological chemistry - 11 Jan 2002

Gonzalez-Garcia Ana, Garrido Elia, Hernandez Carmen, Alvarez Beatriz, Jimenez Concepcion, Cantrell Doreen A, Pullen Nicholas, Carrera Ana C

Abstract excerpt

The serine/threonine kinase p70 S6 kinase (p70S6K) phosphorylates the 40 S ribosomal protein S6, modulating the translation of an mRNA subset that encodes ribosomal proteins and translation elongation factors. p70S6K is activated in response to mitogenic stimuli and is required for progression through the G(1) phase of the cell cycle and for cell growth. Activation of p70S6K is regulated by phosphorylation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enzyme Activation
Share to Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Kinase C

Share to Protein Serine-Threonine Kinases

Share to Protein Subunits

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins c-akt

Share to Ribosomal Protein S6 Kinases

Source

Identifiers

PMID: 11684675
DOI: 10.1074/jbc.M103808200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation.PMID 11684675Read ↗

Structural and functional analysis of pp70S6k.Semantic proximity Read ↗

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase.Semantic proximity Read ↗

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.Semantic proximity Read ↗

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.Semantic proximity Read ↗

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.Semantic proximity Read ↗

The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k.Semantic proximity Read ↗

Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1.Semantic proximity Read ↗

The Multifaceted Role of S6K1 in Cellular Regulation and Disease: Structural Insights, Isoform-Specific Functions, and Therapeutic PotentialSemantic proximity Read ↗

The Multifaceted Role of S6K1 in Cellular Regulation: Structural Insights, Isoform-Specific Functions, and Therapeutic PotentialSemantic proximity Read ↗

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a).Semantic proximity Read ↗

14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity.Semantic proximity Read ↗

The translation regulatory subunit eIF3f controls the kinase-dependent mTOR signaling required for muscle differentiation and hypertrophy in mouse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.