Article
GCKR links the Bcr-Abl oncogene and Ras to the stress-activated protein kinase pathway.
Blood - 15 Feb 1999
Shi C S, Tuscano J M, Witte O N, Kehrl J H
Abstract excerpt
The Bcr-Abl oncogene, found in Philadelphia chromosome-positive myelogenous leukemia (CML), activates Ras and triggers the stress-activated protein kinase (SAPK or Jun NH2-terminal kinase [JNK]) pathway. Interruption of Ras or SAPK activation dramatically reduces Bcr-Abl-mediated transformation....
Topics
- Calcium-Calmodulin-Dependent Protein Kinases
- Fusion Proteins, bcr-abl
- Gene Expression Regulation, Neoplastic
- Germinal Center Kinases
- Humans
- JNK Mitogen-Activated Protein Kinases
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Mitogen-Activated Protein Kinases
- Mutation
- Protein Serine-Threonine Kinases
- Signal Transduction
- Tumor Cells, Cultured
- ras Proteins