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Article

GCKR links the Bcr-Abl oncogene and Ras to the stress-activated protein kinase pathway.

Blood - 15 Feb 1999

Shi C S, Tuscano J M, Witte O N, Kehrl J H

Abstract excerpt

The Bcr-Abl oncogene, found in Philadelphia chromosome-positive myelogenous leukemia (CML), activates Ras and triggers the stress-activated protein kinase (SAPK or Jun NH2-terminal kinase [JNK]) pathway. Interruption of Ras or SAPK activation dramatically reduces Bcr-Abl-mediated transformation. Here, we report that Bcr-Abl through a Ras-dependent pathway signals the serine/threonine protein kinase GCKR (Germinal...

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Share to Calcium-Calmodulin-Dependent Protein Kinases
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Mitogen-Activated Protein Kinases

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Source

Identifiers

PMID: 9949177

Genes

GCKR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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