Allelic exclusion of alpha chains in TCRs.

doi:10.1093/intimm/6.6.881

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Article

Allelic exclusion of alpha chains in TCRs.

International immunology - 1 Jun 1994

Mason D

Abstract excerpt

Although the beta chains of alpha beta+ T cells exhibit allelic exclusion it has recently been shown that approximately 20-30% of such cells express both alpha chain alleles on their surface. Potentially these cells have dual specificity, and it has been suggested that they may play a role in aut...

Topics

Alleles
Autoimmunity
Cell Differentiation
Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
Humans
Models, Genetic
Receptors, Antigen, B-Cell
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocytes

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