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Article

Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc.

British journal of cancer - 9 Sept 2002

Roccato E, Miranda C, Ranzi V, Gishizki M, Pierotti M A, Greco A

Abstract excerpt

The thyroid TRK-T3 oncogene, produced by a chromosomal translocation, is a chimeric, constitutively activated version of the NTRK1/NGF receptor and it is able to transform NIH3T3 cells and differentiate PC12 cells. TRK-T3 oncoprotein triggers multiple signal transduction pathways. Among others, TRK-T3 binds and phosphorylates the Shc and SNT1/FRS2 adaptor proteins both involved in coupling the receptor tyrosine...

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Share to Adaptor Proteins, Vesicular Transport
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to In Situ Nick-End Labeling

Share to Receptor, trkA

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Share to Src Homology 2 Domain-Containing, Transforming Protein 1

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Source

Open in PubMed Open full text

Identifiers

PMID: 12237775
DOI: 10.1038/sj.bjc.6600544
PMCID: PMC2364237

Genes

FRS2
NGF
NTRK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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