Binding specificity and mutational analysis of the phosphotyrosine binding domain of the brain-specific adaptor protein ShcC.

doi:10.1074/jbc.271.20.11787

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Article

Binding specificity and mutational analysis of the phosphotyrosine binding domain of the brain-specific adaptor protein ShcC.

The Journal of biological chemistry - 17 May 1996

O'Bryan J P, Martin C B, Songyang Z, Cantley L C, Der C J

Abstract excerpt

Shc proteins (hereafter referred to as ShcA) represent major substrates of tyrosine phosphorylation by a wide variety of growth factors and cytokines. We have recently described a novel ShcA-like protein, ShcC, which like ShcA contains an NH2-terminal phosphotyrosine binding domain (PTB), a centr...

Topics

Amino Acid Sequence
Binding Sites
Brain Chemistry
ErbB Receptors
Humans
Molecular Sequence Data
Mutation
Phosphotyrosine
Proteins
Structure-Activity Relationship

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