Article
Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells.
The international journal of biochemistry & cell biology - 1 Jan 2018
Suen K M, Lin C C, Seiler C, George R, Poncet-Montange G, Biter A B, Ahmed Z, Arold S T, Ladbury J E
Abstract excerpt
Scaffold proteins play important roles in regulating signalling network fidelity, the absence of which is often the basis for diseases such as cancer. In the present work, we show that the prototypical scaffold protein Shc is phosphorylated by the extracellular signal-regulated kinase, Erk. In addition, Shc threonine phosphorylation is specifically up-regulated in two selected triple-negative breast cancer (TNBC)...
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