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Article

Shc products are substrates of erbB-2 kinase.

Oncogene - 1 Aug 1993

Segatto O, Pelicci G, Giuli S, Digiesi G, Di Fiore P P, McGlade J, Pawson T, Pelicci P G

Abstract excerpt

The shc genes encodes three widely expressed proteins of 46, 52 and 66 kDa. Overexpression of p46shc and p52shc in NIH3T3 fibroblasts induces a tumorigenic phenotype. Shc products are phosphorylated on tyrosine by the activated epidermal growth factor receptor (EGFR) and become physically associa...

Topics

3T3 Cells
Adaptor Proteins, Signal Transducing
Adaptor Proteins, Vesicular Transport
Amino Acid Sequence
Animals
Mice
Molecular Sequence Data
Mutation
Phosphorylation
Protein-Tyrosine Kinases
Proteins
Proto-Oncogene Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, ErbB-2

Shc Signaling Adaptor Proteins

Signal Transduction

Src Homology 2 Domain-Containing, Transforming Protein 1

Tyrosine

Source

Identifiers

PMID: 8101647

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8101647-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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