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Article

Domain-specific function of ShcC docking protein in neuroblastoma cells.

Oncogene - 28 Apr 2005

Miyake Izumi, Hakomori Yuko, Misu Yoko, Nakadate Hisaya, Matsuura Nobuo, Sakamoto Michiie, Sakai Ryuichi

Abstract excerpt

ShcC is a family member of the Shc docking proteins that possess two different phosphotyrosine-binding motifs and conduct signals as Grb2-binding substrates of various receptor tyrosine kinases. We have recently shown that some neuroblastoma cell lines, such as NB-39-nu cells, express a protein complex of hyperphosphorylated ShcC and anaplastic lymphoma kinase (ALK), which is self-activated by gene amplification....

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Identifiers

PMID: 15735675
DOI: 10.1038/sj.onc.1208523

Genes

ALK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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