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Article

Effect of mutations downstream of the internal ribosome entry site on initiation of poliovirus protein synthesis.

Journal of virology - 1 Oct 1994

Hellen C U, Pestova T V, Wimmer E

Abstract excerpt

Initiation of poliovirus translation is mediated by a large, structured segment of the 5' nontranslated region known as the internal ribosome entry site (IRES) and normally occurs 155 nucleotides (nt) downstream of the IRES at AUG743 (the AUG at nucleotide 743). Functional AUG codons introduced at nt 611 or 614 reduced initiation at AUG743 by 10 to 40% in vitro but had no effect on virus phenotype. To investigate...

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Identifiers

PMID: 8083971
DOI: 10.1128/JVI.68.10.6312-6322.1994
PMCID: PMC237052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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