Article
Effect of mutations downstream of the internal ribosome entry site on initiation of poliovirus protein synthesis.
Journal of virology - 1 Oct 1994
Hellen C U, Pestova T V, Wimmer E
Abstract excerpt
Initiation of poliovirus translation is mediated by a large, structured segment of the 5' nontranslated region known as the internal ribosome entry site (IRES) and normally occurs 155 nucleotides (nt) downstream of the IRES at AUG743 (the AUG at nucleotide 743). Functional AUG codons introduced a...
Topics
- Base Sequence
- Codon
- DNA, Ribosomal
- DNA, Viral
- Genes, Viral
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Nucleic Acid Conformation
- Oligodeoxyribonucleotides
- Phenotype
- Plasmids
- Poliovirus
- Protein Biosynthesis
- RNA, Messenger
- Ribosomes
- Thermodynamics