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Article

Starting window, a distinct element in the cap-independent internal initiation of translation on picornaviral RNA.

Journal of molecular biology - 19 Aug 1994

Pilipenko E V, Gmyl A P, Maslova S V, Belov G A, Sinyakov A N, Huang M, Brown T D, Agol V I

Abstract excerpt

Initiation of translation on picornaviral RNA templates occurs via cap-independent ribosome binding to a cis-acting element, internal ribosome entry site (IRES). Mapping of the starting point of translation relative to the IRES was attempted using Theiler's murine encephalomyelitis virus (TMEV) RNA as a model. The possibility that the starting point is determined by the conserved oligopyrimidine upstream of the...

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PMID: 8064856
DOI: 10.1006/jmbi.1994.1516

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