Article
Stability of a stem-loop involving the initiator AUG controls the efficiency of internal initiation of translation on hepatitis C virus RNA.
RNA (New York, N.Y.) - 1 Oct 1996
Honda M, Brown E A, Lemon S M
Abstract excerpt
The initiation of translation on the positive-sense RNA genome of hepatitis C virus (HCV) is directed by an internal ribosomal entry site (IRES) that occupies most of the 341-nt 5' nontranslated RNA (5'NTR). Previous studies indicate that this IRES differs from picornaviral IRESs in that its acti...
Topics
- Antigens, Viral
- Base Sequence
- Carcinoma, Hepatocellular
- Codon, Initiator
- Flaviviridae
- Hepacivirus
- Humans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Peptide Chain Initiation, Translational
- RNA, Viral