Functional Characterization of the Internal Ribosome Entry Site of eIF4G mRNA

doi:10.1074/jbc.273.9.5006

Article

Functional Characterization of the Internal Ribosome Entry Site of eIF4G mRNA

1 Feb 1998

Abstract excerpt

The eIF4 group initiation factors are required for cap-dependent translation initiation. Infection of mammalian cells by picornaviruses results in proteolytic cleavage of one of these factors, eIF4G, which severely restricts cap-dependent initiation but permits cap-independent initiation to proceed from an internal ribosome entry site (IRES) in picornaviral RNAs. The first 357 nucleotides (nt) of the...

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