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Article

A conserved AUG triplet in the 5' nontranslated region of poliovirus can function as an initiation codon in vitro and in vivo.

Virology - 1 Nov 1994

Pestova T V, Hellen C U, Wimmer E

Abstract excerpt

Poliovirus translation is initiated at AUG743, 154 nt downstream of a conserved heptanucleotide CUUAUGG at the 3' border of the internal ribosome entry site. AUG586 is part of this motif and is normally not an initiation codon, but was activated following alteration of its context from CUUAUGG to ACCAUGG. Initiation at AUG586 was efficient and yielded a 7.2-kDa polypeptide translated in an open reading frame that...

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PMID: 7941341
DOI: 10.1006/viro.1994.1588

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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