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Article

Structural determinants of an internal ribosome entry site that direct translational reading frame selection.

Nucleic acids research - 1 Aug 2014

Ren Qian, Au Hilda H T, Wang Qing S, Lee Seonghoon, Jan Eric

Abstract excerpt

The dicistrovirus intergenic internal ribosome entry site (IGR IRES) directly recruits the ribosome and initiates translation using a non-AUG codon. A subset of IGR IRESs initiates translation in either of two overlapping open reading frames (ORFs), resulting in expression of the 0 frame viral structural polyprotein and an overlapping +1 frame ORFx. A U-G base pair adjacent to the anticodon-like pseudoknot of the...

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Identifiers

PMID: 25038250
DOI: 10.1093/nar/gku622
PMCID: PMC4132737

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Source receipt: pubmed, retrieved 7 Sept 2026.

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