Internal initiation of translation of hepatitis C virus RNA: the ribosome entry site is at the authentic initiation codon.

Article

Internal initiation of translation of hepatitis C virus RNA: the ribosome entry site is at the authentic initiation codon.

RNA (New York, N.Y.) - 1 Sept 1996

Reynolds J E, Kaminski A, Carroll A R, Clarke B E, Rowlands D J, Jackson R J

Abstract excerpt

Hepatitis C viral (HCV) RNA includes an internal ribosome entry segment (IRES) that extends some 30 nt into the coding region and promotes internal initiation of translation at the authentic initiation codon at nt 342. The 5'-boundary of this IRES was mapped by in vitro translation and transfecti...

Topics

Base Sequence
Binding Sites
Codon, Initiator
Hepacivirus
Molecular Sequence Data
Mutation
Protein Biosynthesis
RNA, Viral
Ribosomes
Trinucleotide Repeats

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