Article
Regulatory role of diacylglycerol kinase gamma in macrophage differentiation of leukemia cells.
Biochemical and biophysical research communications - 23 May 2003
Yamada Keiko, Sakane Fumio, Imai Shin ichi, Tsushima Shuichi, Murakami Tomohiro, Kanoh Hideo
Abstract excerpt
Although nine diacylglycerol kinase (DGK) isozymes have been identified, our knowledge of their individual functions is still limited. Here we report that the levels of DGKgamma mRNA/protein in human leukemia HL-60 and U937 cells were rapidly and markedly decreased upon cellular differentiation into macrophages. In contrast, the enzyme expression remained almost unchanged in granulocytic differentiation pathway....
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