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Differentiation of human monocytic cell lines confers susceptibility to Bacillus anthracis lethal toxin

10 Dec 2004

Abstract excerpt

Anthrax lethal toxin (LT) is comprised of protective antigen and lethal factor. Lethal factor enters mammalian cells in a protective antigen-dependent process and cleaves mitogen-activated protein kinase kinases. Although LT has no observable effect on many cell types, it causes necrosis in macrophages derived from certain mouse strains and apoptosis in activated mouse macrophages. In this study, we observed that...

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PMID: 15659071
DOI: 10.1111/j.1462-5822.2004.00458.x

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