Article
Regulatory properties and cellular redistribution of zinc during macrophage differentiation of human leukemia cells.
Journal of structural biology - 1 Jul 2006
Glesne David, Vogt Stefan, Maser Jorg, Legnini Daniel, Huberman Eliezer
Abstract excerpt
Many proteins require the binding of trace metals such as Ca, Fe, Cu, or Zn, which may modulate their structure, function, or activity. To determine if there were any overall changes in metalloprotein distribution or metal concentration during the process of macrophage differentiation we induced human myeloid HL-60 leukemia cells with phorbol 12-myristate 13-acetate (PMA) and quantitatively mapped their metal...
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