Article
PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jan 2006
Bender Andrew T, Beavo Joseph A
Abstract excerpt
Monocyte-to-macrophage differentiation with the cytokine granulocyte-macrophage colony-stimulating factor induces expression of the cyclic nucleotide phosphodiesterase PDE1B2. However, what role PDE1B2 plays in macrophage biology has not been elucidated. We have addressed this question by inhibiting PDE1B2 induction by using RNA interference. Using a retrovirus-based system, we created HL-60 stable cell lines...
Topics
- Antigens, CD
- Cell Differentiation
- Cell Line, Tumor
- Cyclic AMP-Dependent Protein Kinases
- Cyclic GMP
- Cyclic Nucleotide Phosphodiesterases, Type 1
- Humans
- Macrophages
- Monocytes
- Phenotype