Article
APC mutations occur early during colorectal tumorigenesis.
Nature - 17 Sept 1992
Powell S M, Zilz N, Beazer-Barclay Y, Bryan T M, Hamilton S R, Thibodeau S N, Vogelstein B, Kinzler K W
Abstract excerpt
Human tumorigenesis is associated with the accumulation of mutations both in oncogenes and in tumour suppressor genes. But in no common adult cancer have the mutations that are critical in the early stages of the tumorigenic process been defined. We have attempted to determine if mutations of the APC gene play such a role in human colorectal tumours, which evolve from small benign tumours (adenomas) to larger...
Topics
- Adenoma
- Alleles
- Base Sequence
- Carcinoma
- Chromosome Mapping
- Colorectal Neoplasms
- Genes, Tumor Suppressor
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction