Article
Deletion of the human retinoblastoma gene in primary leukemias.
Blood - 15 Nov 1990
Chen Y C, Chen P J, Yeh S H, Tien H F, Wang C H, Tang J L, Hong R L
Abstract excerpt
As an initial step in evaluating the role of tumor suppressor genes in leukemogenesis, we surveyed primary leukemia cells from 130 patients for possible deletion of the retinoblastoma susceptibility (Rb) gene by Southern blot analysis. Two of them clearly showed homozygous deletion of Rb alleles. The first patient was a pre-B acute lymphoid leukemia (ALL) associated with a cytogenetic translocation:...
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