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Article

Structural alterations at the putative retinoblastoma locus in some human leukemias and preleukemia.

Cancer genetics and cytogenetics - 1 Oct 1990

Hansen M F, Morgan R, Sandberg A A, Cavenee W K

Abstract excerpt

Homozygous loss of alleles of the retinoblastoma susceptibility locus (RB1) has been implicated in the onset of many different solid tumors. Heterozygous deletions of chromosome 13q14, the region containing the RB1 locus, have been observed by us in several subvariants of leukemia and preleukemia. We examined four cases of leukemia and one case of preleukemia for homozygous inactivation of the RB1 locus; in at...

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PMID: 2397469
DOI: 10.1016/0165-4608(90)90159-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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