Structural alterations at the putative retinoblastoma locus in some human leukemias and preleukemia.

doi:10.1016/0165-4608(90)90159-8

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Article

Structural alterations at the putative retinoblastoma locus in some human leukemias and preleukemia.

Cancer genetics and cytogenetics - 1 Oct 1990

Hansen M F, Morgan R, Sandberg A A, Cavenee W K

Abstract excerpt

Homozygous loss of alleles of the retinoblastoma susceptibility locus (RB1) has been implicated in the onset of many different solid tumors. Heterozygous deletions of chromosome 13q14, the region containing the RB1 locus, have been observed by us in several subvariants of leukemia and preleukemia...

Topics

Adolescent
Adult
Aged
Alleles
Child
Chromosome Deletion
Chromosomes, Human, Pair 13
Female
Genetic Markers
Homozygote
Humans
Karyotyping
Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia, Myeloid, Acute
Male
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed

Identifiers

PMID: 2397469
DOI: 10.1016/0165-4608(90)90159-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2397469-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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