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Minimal 16q Genomic Loss Implicates Cadherin-11 in Retinoblastoma

1 Sept 2004

Abstract excerpt

Retinoblastoma is initiated by loss of both RB1 alleles. Previous studies have shown that retinoblastoma tumors also show further genomic gains and losses. We now define a 2.62 Mbp minimal region of genomic loss of chromosome 16q22, which is likely to contain tumor suppressor gene(s), in 76 retinoblastoma tumors, using loss of heterozygosity (30 of 76 tumors) and quantitative multiplex PCR (71 of 76 tumors). The...

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PMID: 15383628
DOI: 10.1158/1541-7786.495.2.9

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