Dominance of wild-type p53-mediated transcriptional activation in breast epithelial cells.

Article

Dominance of wild-type p53-mediated transcriptional activation in breast epithelial cells.

Oncogene - 19 Sept 1996

Davis P, Bazar K, Huper G, Lozano G, Marks J, Iglehart J D

Abstract excerpt

The p53 gene is a recessive oncogene whose loss of function can result in cell transformation. Approximately 25% of human breast cancers contain missense mutations in one p53 allele, leading to inactivation of the mutated protein. In almost all of these cases, the wild-type allele is also lost. H...

Topics

Adult
Alleles
Breast
Breast Neoplasms
Epithelium
Female
Genes, Dominant
Genes, p53
Humans
Mutation
Promoter Regions, Genetic
Transcriptional Activation
Transfection
Tumor Cells, Cultured
Tumor Suppressor Protein p53

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