Article
p53Val135 temperature sensitive mutant suppresses growth of human breast cancer cells.
Breast cancer research and treatment - 1 Jan 1994
Eliyahu D, Evans S, Rosen N, Eliyahu S, Zwiebel J, Paik S, Lippman M
Abstract excerpt
One common step in the malignant progression of a wide variety of human cancers seems to be inactivation of the p53 gene, via point mutation or deletion or both; or overexpression of mutated protein with dominant transforming activity. This study shows a suppressive effect of wild type p53 on the growth of human breast cancer cells. Introduction of wild type p53 versus mutant into five human breast cancer cell...
Topics
- 3T3 Cells
- Animals
- Breast Neoplasms
- Cell Division
- Female
- Genes, p53
- Humans
- Mice
- Mutation
- Temperature
- Transfection
- Tumor Cells, Cultured