Simple stochastic theory of stem cell differentiation is not simultaneously consistent with crypt extinction probability and the expansion of mutated clones.

Abstract excerpt

It is shown that a simple Galton-Watson branching process model of the stem-cell pool in intestinal crypts is not simultaneously consistent with observations of the dynamics of replacement of normal by mutant crypt stem cells and other observations which put limits on the probability of crypt loss through extinction of all stem cells. This is because the limits on extinction probability forces the probability...

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