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Intestinal Stem Cell Replacement Follows a Pattern of Neutral Drift

23 Sept 2010

Abstract excerpt

With the capacity for rapid self-renewal and regeneration, the intestinal epithelium is stereotypical of stem cell-supported tissues. Yet the pattern of stem cell turnover remains in question. Applying analytical methods from population dynamics and statistical physics to an inducible genetic labeling system, we showed that clone size distributions conform to a distinctive scaling behavior at short times. This...

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PMID: 20929733
DOI: 10.1126/science.1196236

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