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Stochastic Dynamics of Hematopoietic Tumor Stem Cells

15 Feb 2007

Abstract excerpt

Many tumors derive from the transformation of normal stem cells into cancer stem cells that retain their self-renewal capacity. This modern view of cancer has provided a natural explanation for the striking parallels which exist between these two different types of self-renewing cells. Here we develop a simple mathematical model to investigate the implications of this concept regarding the evolution of tumors in...

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PMID: 17329969
DOI: 10.4161/cc.6.4.3853

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