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Article

Dynamics of mutant cells in hierarchical organized tissues.

PLoS computational biology - 1 Dec 2011

Werner Benjamin, Dingli David, Lenaerts Tom, Pacheco Jorge M, Traulsen Arne

Abstract excerpt

Most tissues in multicellular organisms are maintained by continuous cell renewal processes. However, high turnover of many cells implies a large number of error-prone cell divisions. Hierarchical organized tissue structures with stem cell driven cell differentiation provide one way to prevent the accumulation of mutations, because only few stem cells are long lived. We investigate the deterministic dynamics of...

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Identifiers

PMID: 22144884
DOI: 10.1371/journal.pcbi.1002290
PMCID: PMC3228763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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