Article
Evidence supporting a signal transduction pathway leading to the radiation-resistant phenotype in human tumor cells.
Biochemical and biophysical research communications - 3 Jan 1997
Pirollo K F, Hao Z, Rait A, Ho C W, Chang E H
Abstract excerpt
A signal transduction pathway, involving oncogenes and their normal counterparts the proto-oncogenes, analogous to that for cell growth and differentiation has been proposed to lead to the phenotype of cellular radioresistance (RR). In this report we provide evidence demonstrating the existence o...
Topics
- Breast
- Carcinoma, Squamous Cell
- Cell Line
- Cell Survival
- Dose-Response Relationship, Radiation
- Female
- Gamma Rays
- Genes, ras
- Head and Neck Neoplasms
- Humans
- Oligonucleotides, Antisense
- Oncogenes
- Ovarian Neoplasms
- Phenotype
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-raf
- Proto-Oncogenes