Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence supporting a signal transduction pathway leading to the radiation-resistant phenotype in human tumor cells.

Biochemical and biophysical research communications - 3 Jan 1997

Pirollo K F, Hao Z, Rait A, Ho C W, Chang E H

Abstract excerpt

A signal transduction pathway, involving oncogenes and their normal counterparts the proto-oncogenes, analogous to that for cell growth and differentiation has been proposed to lead to the phenotype of cellular radioresistance (RR). In this report we provide evidence demonstrating the existence of such a pathway by using antisense oligonucleotides (ASO) to reverse the RR phenotype. Utilizing ASO directed against...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Survival

Share to Genes, ras

Share to Oncogenes

Share to Phenotype

Share to Protein Serine-Threonine Kinases

Share to Proto-Oncogene Proteins

Source

Identifiers

PMID: 9020045
DOI: 10.1006/bbrc.1996.5922

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence supporting a signal transduction pathway leading to the radiation-resistant phenotype in human tumor cells.PMID 9020045Read ↗

Oncogene- transformed NIH 3T3 cells display radiation resistance levels indicative of a signal transduction pathway leading to the radiation-resistant phenotype.Semantic proximity Read ↗

Ras regulation of radioresistance in cell culture.Semantic proximity Read ↗

An anti-sense construct of full-length ATM cDNA imposes a radiosensitive phenotype on normal cells.Semantic proximity Read ↗

Effects of c-raf-1 and c-myc expression on radiation response in an in vitro model of human small-cell-lung carcinoma.Semantic proximity Read ↗

Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines.Semantic proximity Read ↗

Adaptation to Arginine Deprivation Leads to a More Aggressive, Therapy-Resistant Phenotype in HNSCC Cells.Semantic proximity Read ↗

Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase.Semantic proximity Read ↗

Human breast cancer progression can be regulated by dominant trans-acting factors in somatic cell hybridization studies.Semantic proximity Read ↗

[The role of proto-oncogene expression in cellular radiosensitivity and radioresistance].Semantic proximity Read ↗

Ribonucleotide reductase inhibition: regulation of the radiosensitive phenotype via NF kappa B and Bcl-2.Semantic proximity Read ↗

Radioresistance induced in rat embryo cells by transfection with the oncogenes H-ras plus v-myc is cell cycle dependent and maximal during S and G2.Semantic proximity Read ↗

Reovirus oncolysis: The Ras/RalGEF/p38 pathway dictates host cell permissiveness to reovirus infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.