Article
The ras oncogene-mediated sensitization of human cells to topoisomerase II inhibitor-induced apoptosis.
Journal of the National Cancer Institute - 3 Feb 1999
Koo H M, Gray-Goodrich M, Kohlhagen G, McWilliams M J, Jeffers M, Vaigro-Wolff A, Alvord W G, Monks A, Paull K D, Pommier Y, Vande Woude G F
Abstract excerpt
BACKGROUND: Among the inhibitors of the enzyme topoisomerase II (an important target for chemotherapeutic drugs) tested in the National Cancer Institute's In Vitro Antineoplastic Drug Screen, NSC 284682 (3'-hydroxydaunorubicin) and NSC 659687 [9-hydroxy-5,6-dimethyl-1-(N-[2(dimethylamino)ethyl]carbamoyl)-6H-pyrido -(4,3-b)carbazole] were the only compounds that were more cytotoxic to tumor cells harboring an...
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