A novel compound, depudecin, induces production of transformation to the flat phenotype of NIH3T3 cells transformed by ras-oncogene.

doi:10.1016/s0006-291x(05)80156-1

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Article

A novel compound, depudecin, induces production of transformation to the flat phenotype of NIH3T3 cells transformed by ras-oncogene.

Biochemical and biophysical research communications - 15 Jan 1992

Sugita K, Yoshida H, Matsumoto M, Matsutani S

Abstract excerpt

A novel compound, depudecin, induced production of the flat phenotype of Ki-ras-transformed NIH3T3 cells at the low concentration of 1 microgram/ml. This effect was reversible. Actin stress fiber was detected in these cells after depudecin treatment. Almost complete reversion to the flat phenotype was observed at 6 h after depudecin addition. The synthesis of ras-mRNA did not decrease enough with depudecin...

Topics

3T3 Cells
Actins
Alkadienes
Animals
Antifungal Agents
Cell Division
Cell Line, Transformed
Cell Transformation, Neoplastic
Epoxy Compounds
Fatty Alcohols
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, ras

Hydroxamic Acids

Kinetics

Mice

Phenotype

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 1731795
DOI: 10.1016/s0006-291x(05)80156-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1731795-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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