Article
Oxamflatin: a novel compound which reverses malignant phenotype to normal one via induction of JunD.
Oncogene - 4 Jul 1996
Sonoda H, Nishida K, Yoshioka T, Ohtani M, Sugita K
Abstract excerpt
In the course of screening for inhibitors of tumorigenic phenotype of K-ras-transformed NIH3T3 cells (DT cells), we found a novel compound, oxamflatin, an aromatic sulfonamide hydroxamate derivative, which induces flat phenotype in these cells and suppresses their anchorage-independent growth. In...
Topics
- 3T3 Cells
- Animals
- Antineoplastic Agents
- Base Sequence
- Cell Division
- Cell Line, Transformed
- Cell Transformation, Viral
- Enzyme Activation
- Fibronectins
- Gene Expression Regulation, Neoplastic
- Hydroxamic Acids
- MAP Kinase Kinase Kinase 1
- Mice
- Molecular Sequence Data
- Neoplasm Proteins
- Oncogene Protein p21(ras)
- Oncogene Proteins v-raf
- Phenotype