Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of anchorage-independent growth of tumor cells by IT-62-B, a new anthracycline.

The Journal of antibiotics - 1 Oct 1997

Tsuchiya K S, Ishii T, Ikeno S, Kunimoto S, Kawauchi T, Otani T, Hori M

Abstract excerpt

IT-62-B, a new anthracycline isolated from fermentation broths of Streptomyces sp. IT-62, reversed certain tumor cell phenotypes in vitro including some of human origin. The observed normal phenotypes were anchorage dependence of cell growth, flattened cell morphology and restoration of actin str...

Topics

Actins
Animals
Anthracyclines
Antibiotics, Antineoplastic
Cell Division
DNA Topoisomerases, Type II
DNA, Neoplasm
Doxorubicin
Gene Expression Regulation, Neoplastic
Genes, fos
Genes, ras
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Tumor Cells, Cultured

Tumor Stem Cell Assay

Source

Identifiers

PMID: 9402991
DOI: 10.7164/antibiotics.50.853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9402991-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Inhibition of anchorage-independent growth of tumor cells by IT-62-B, a new anthracycline.PMID 9402991Read ↗

Phenotypic reversion induced by anthracyclines in ras oncogene-expressed cells; structure-activity relationships.Semantic proximity Read ↗

Actinomycin V Suppresses Human Non-Small-Cell Lung Carcinoma A549 Cells by Inducing G2/M Phase Arrest and Apoptosis via the p53-Dependent PathwaySemantic proximity Read ↗

p53-Independent Expression of p21CIP1/WAF1in Plasmacytic Cells during G2Cell Cycle Arrest Induced byActinobacillus actinomycetemcomitansCytolethal Distending ToxinSemantic proximity Read ↗

Effect of butyrate analogues on proliferation and differentiation in human neuroblastoma cell lines.Semantic proximity Read ↗

Tyrosine kinase inhibitor-induced differentiation of K-562 cells: alterations of cell cycle and cell surface phenotype.Semantic proximity Read ↗

(+)-Terrein inhibits human hepatoma Bel-7402 proliferation through cell cycle arrestSemantic proximity Read ↗

Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic ViewpointSemantic proximity Read ↗

Protecting the normal in order to better kill the cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.