Article
A Chinese hamster fibroblast mutant defective in thrombin-induced signaling has a low level of phospholipase C-beta 1.
The Journal of biological chemistry - 26 Aug 1994
Fee J A, Monsey J D, Handler R J, Leonis M A, Mullaney S R, Hope H M, Silbert D F
Abstract excerpt
A mutant fibroblast, 2A4b, was isolated from the Chinese hamster lung cell line CCL39 by a previously described selection (Rath, H. M., Doyle, G. A. R., and Silbert, D. F. (1989) J. Biol. Chem. 264, 13387-13390) for cells deficient in thrombin-induced signaling. Although the antiporter activation...
Topics
- Animals
- Arachidonic Acid
- Biological Transport
- Cell Compartmentation
- Cricetinae
- Cricetulus
- Down-Regulation
- Fibroblasts
- Isoenzymes
- Mutation
- Phosphatidylinositols
- Phospholipase C beta
- Phospholipases A
- Signal Transduction
- Sodium-Hydrogen Exchangers
- Substrate Specificity
- Tetradecanoylphorbol Acetate
- Thrombin