Characterization of phosphatidylinositol-specific phospholipase C defects associated with thrombin-induced mitogenesis.

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Article

Characterization of phosphatidylinositol-specific phospholipase C defects associated with thrombin-induced mitogenesis.

The Journal of biological chemistry - 25 Feb 1990

Rath H M, Fee J A, Rhee S G, Silbert D F

Abstract excerpt

In a previous paper (Rath, H. M., Doyle, G. A. R., and Silbert, D. F. (1989) J. Biol. Chem. 264, 13387-13390), we reported a selection for the isolation of Chinese hamster lung fibroblasts (CCL39) defective in thrombin-induced mitogenesis. One mutant, D1-6b, had decreased production of inositol phosphates when challenged with activators of phosphatidylinositol turnover and extracts of this mutant showed a marked...

Topics

Animals
Cell Division
Cell Line
Chromatography, Gel
Chromatography, Ion Exchange
Cricetinae
Cricetulus
Cytosol
Immunoblotting
Kinetics
Liposomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lung

Molecular Weight

Mutation

Phosphatidylinositols

Protein Denaturation

Thermodynamics

Thrombin

Source

Open in PubMed

Identifiers

PMID: 2303441

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2303441-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Characterization of phosphatidylinositol-specific phospholipase C defects associated with thrombin-induced mitogenesis.PMID 2303441Read ↗

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