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Article

BCR-ABL-transformed GMP as myeloid leukemic stem cells

11 Nov 2008

Abstract excerpt

During blast crisis of chronic myelogenous leukemia (CML), abnormal granulocyte macrophage progenitors (GMP) with nuclear beta-catenin acquire self-renewal potential and may function as leukemic stem cells (Jamieson et al. N Engl J Med, 2004). To develop a mouse model for CML-initiating GMP, we expressed p210(BCR-ABL) in an established line of E2A-knockout mouse BM cells that retain pluripotency in ex vivo...

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PMID: 19004799
DOI: 10.1073/pnas.0808303105

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