Article
Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia.
Blood - 23 Dec 2010
Wang Jinyong, Liu Yangang, Li Zeyang, Du Juan, Ryu Myung-Jeom, Taylor Philip R, Fleming Mark D, Young Ken H, Pitot Henry, Zhang Jing
Abstract excerpt
Oncogenic NRAS mutations are frequently identified in myeloid diseases involving monocyte lineage. However, its role in the genesis of these diseases remains elusive. We report a mouse bone marrow transplantation model harboring an oncogenic G12D mutation in the Nras locus. Approximately 95% of recipient mice develop a myeloproliferative disease resembling the myeloproliferative variant of chronic myelomonocytic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.