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Article

Multistep pathogenesis of leukemia via the MLL-AF4 chimeric gene/Flt3 gene tyrosine kinase domain (TKD) mutation-related enhancement of S100A6 expression.

Experimental hematology - 1 Jun 2009

Yamaguchi Hiroki, Hanawa Hideki, Uchida Naoya, Inamai Mitsuharu, Sawaguchi Kazuhiro, Mitamura Yoshio, Shimada Takashi, Dan Kazuo, Inokuchi Koiti

Abstract excerpt

OBJECTIVE: Concerning MLL-AF4 leukemogenesis, previous mouse models suggest that the tumorigenesis capacity of MLL-AF4 alone is insufficient for causing leukemia. Based on the finding that an Fms-like tyrosine kinase 3 (Flt3) gene mutation in the tyrosine kinase domain (TKD) was observed in appro...

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Identifiers

PMID: 19463771
DOI: 10.1016/j.exphem.2009.02.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19463771-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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